A mysterious virus suddenly strikes down millions. Three days later, its victims awake with a single purpose: spread the Infection. As the world lurches toward the apocalypse, some of the Infected continue to change, transforming into horrific monsters.

In one American city, a small group struggles to survive. Sarge, a tank commander hardened by years of fighting in Afghanistan. Wendy, a cop still fighting for law and order in a lawless land. Ethan, a teacher searching for his lost family. Todd, a high school student who sees second chances in the end of the world. Paul, a minister who wonders why God has forsaken his children. And Anne, their mysterious leader, who holds an almost fanatical hatred for the Infected.

Together, they fight their way to a massive refugee camp where thousands have made a stand. There, what's left of the government will ask them to accept a mission that will determine the survival of them all—a dangerous journey back onto the open road and into the very heart of Infection.