Medicine men and members of the Plant Watchers society report that sacred healing plants are disappearing from the Rez. In an effort to locate and protect the rare plants, the tribal council asks Rose for help. She faces strong opposition both from healers reluctant to reveal their secret herb-gathering spots and from people who think the Rez should be cultivated with genetically-engineered plants instead of native species.
Rose is shocked to discover that many plants appear to have been stolen, perhaps for the lucrative market for alternative and natural medications. Soon after her notes and maps are stolen, a Navajo man is found dead near a gathering site. Rose is convinced that he was murdered by the plant thief.

Rose has picked up a trick or two from Ella Clah, her police officer daughter; she begins an independent investigation that soon has her up to her neck in trouble.