It's a team-up of the most powerful forces in the Marvel Ultimate Universe! The deadliest super-villains in the world the Green Goblin, Electro, Doctor Octopus, Kraven the Hunter and the Sandman have been taken prisoner by Nick Fury & S.H.I.E.L.D.

Why have they been brought together? And who is the mysterious 6th member of this "Sinister Six"? When together they escape and the Green Goblin's horrific scheme becomes clear, it's up to the government's superhuman task force the Ultimates to take them down and bring them back in. But where is Spider-Man when you need him the most?

Collecting: Ultimate Spider-Man 46 & Ultimate Six 1-7