Four distinctive characters whose lives were forever changed by encounters with Preacher's Jesse Custer take center stage in this volume. Included: The Saint of Killers, telling the origin of this troubled, violent figure from the Old West, and The Story of You-Know-Who, in which a disaffected loser tries to escape the influence of his abusive sheriff father with tragic, yet comical, results, and more.

Collects: Preacher Special: Saint of Killers #1–4, Preacher Special: The Story of You-Know-Who, Preacher Special: The Good Old Boys