Thisbe Nissen is the author of three novels, Our Lady of the Prairie (Houghton Mifflin Harcourt, 2018), Osprey Island (Knopf, 2004), The Good People of New York (Knopf, 2001), and a story collection, Out of the Girls' Room and into the Night (University of Iowa Press, 1999, winner of the John Simmons Short Fiction Award). She is also the co-author with Erin Ergenbright of The Ex-Boyfriend Cookbook, a collection of stories, recipes, and art collages. Her fiction has been published in The Iowa Review, The American Scholar, Seventeen, and The Virginia Quarterly Review, and anthologized in The Iowa Award: The Best Stories 1991-2000 and Best American Mystery Stories. Her nonfiction has appeared in Vogue, Glamour, Preservation and The Believer, and is featured in several essay anthologies.

She has been the recipient of fellowships from the James Michener-Copernicus Society, The University of Iowa, Bread Loaf Writers' Conference, Yaddo, and the MacDowell Colony, and was the 19th Zale Writer-in-Residence at Tulane University. She has taught at Columbia University, the Iowa Writers' Workshop, Brandeis University, The New School's Eugene Lang College and in the low residency MFA program at Pacific University. These days, she teaches undergrad, MFA and PhD students at Western Michigan University.

She and her husband, Jay Baron Nicorvo, are parents of two rescue cats, many sprightly chickens, and one intriguing human child. They dream, one day, of raising goats.