Wayne Johnston was born and raised in Goulds, Newfoundland. After a brief stint in pre-Med, Wayne obtained a BA in English from Memorial University. He worked as a reporter for the St. John's Daily News before deciding to devote himself full-time to writing.

En route to being published, Wayne earned an MA in Creative Writing from the University of New Brunswick. Then he got off to a quick start. His first book, The Story of Bobby O'Malley, published when he was 27 years old, won the WH Smith/Books in Canada First Novel award for the best first novel published in the English language in Canada in that year. The Divine Ryans was adapted to a film, for which Wayne wrote the screenplay. Baltimore's Mansion, a memoire dealing with his grandfather, his father and Wayne himself, won the Charles Taylor Prize. Both The Colony of Unrequited Dreams and The Navigator of New York were on bestseller lists in Canada and have been published in the US, Britain, Germany, Holland, China and Spain. Colony was identified by the Globe and Mail newspaper as one of the 100 most important Canadian books ever produced.